INHIBITION OF DYRK1B SUPPRESSES INFLAMMATION IN ALLERGIC CONTACT DERMATITIS MODEL AND TH1/TH17 IMMUNE RESPONSE

Abstract Allergic contact dermatitis (ACD) is a type IV hypersensitivity mainly mediated by Th1/Th17 immune response.Topical corticosteroid is currently the first-line treatment for allergic contact dermatitis (ACD) and systemic administration of immunosuppressive drugs are used in patients with severe disseminated cases.However, increased incredib

Honeybee royal jelly is reported to have body-enlarging effects in holometabolous insects such as the honeybee, fly and silkmoth, but its effect in non-holometabolous insect species has not yet been examined.The present study confirmed the att nighthawk hotspot body-enlarging effect in silkmoths fed an artificial diet instead of mulberry leaves use